منابع مشابه
Voltage-Gated Sodium Channels Modulation by Bothutous Schach Scorpion Venom
Buthotus schach is one of the dangers scorpion in Iran that belong to the Buthidae family. Toxins are existing in venom scorpion, modulate the ion channels by blocking or opening the pore of the channel or by altering the voltage gating and useful as pharmacological tools. In the present study, we investigated the effect of venom and its obtained fractions by gel filtrations on electrophysiolog...
متن کاملCardiac Sodium Channels
Effects of flecainide, a potent antiarrhythmic agent, on sodium channel availability was investigated in guinea pig single cardiac cells by the whole-cell voltage-clamp technique. Sodium current (INa) experiments were performed at 170 C, and maximum upstroke velocity (Vmax) experiments were performed at 370 C. Flecainide (3 ,M) caused little tonic block, but reduced sodium channel availability ...
متن کاملSodium channels and pain
Although it is well established that hyperexcitability andyor increased baseline sensitivity of primary sensory neurons can lead to abnormal burst activity associated with pain, the underlying molecular mechanisms are not fully understood. Early studies demonstrated that, after injury to their axons, neurons can display changes in excitability, suggesting increased sodium channel expression, an...
متن کاملSubunits of Sodium Channels
The purified Na+ channel from rat brain consists of a (260 kDa), Bl (36 kDa), and ,192 (33 kDa) subunits. Pure ,t?l subunits were prepared from purified rat brain Na+ channels which had been adsorbed to hydroxylapatite resin and used to prepare specific anti-81 subunit antiserum. Antibodies purified from this antiserum by antigen affinity chromatography immunoprecipitate 12SI-labeled, purified ...
متن کاملSodium channels amplify spine potentials.
Dendritic spines mediate most excitatory synapses in the brain. Past theoretical work and recent experimental evidence have suggested that spines could contain sodium channels. We tested this by measuring the effect of the sodium channel blocker tetrodotoxin (TTX) on depolarizations generated by two-photon uncaging of glutamate on spines from mouse neocortical pyramidal neurons. In practically ...
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ژورنال
عنوان ژورنال: Brain and Neuroscience Advances
سال: 2018
ISSN: 2398-2128,2398-2128
DOI: 10.1177/2398212818810684